Indima yesistim somzimba ekuveliseni abantu iphezulu kakhulu. Iingcali zenzululwazi ziye zafakazela ukuba malunga nesihlanu kwabantu abanengxaki yokungabonakali kwengxaki abangenayo intsingiselo ye-immune system. Enye yeziganeko ezinxulumene nesistim somzimba, oko kunokukhokelela ekungabikho komntwana, kukuqulunqwa kwemizimba ye-antispermal.
La mabhunga athatha inxaxheba kwinkqubo yokusebenzisana kwegetetes (gametes), engavumeli i-spermatozoa ukungena kwiigobolondo zeqanda. Indlela abayenzayo ngayo ayisayiqondwa ngokucacileyo, kodwa sele sele icacile ukuba ezi zikhuhlane zivimbela impendulo ye-acrosomal yeeseli ze-spermatozoon, ezenza njengenye yezinto eziyimfuneko zokuchumisa ngokuphumelelayo. Ukuba elinye lamalingani, amadoda okanye amabhinqa, anemizimba ye-antispermic, ngoko umgangatho weembryos udla ngaphezu kobantu abangenawo amanqweno anjalo, okunciphisa ukuphumelela kwonyango lokungabikho kwengqondo nge-vitro fertilization. Ukuba i-ACAT ayiphumelelwanga ngeteknoloji egcinayo, indlela ekhethiweyo ngakumbi yeebini ezi zibini ukufakwa kwe-spermatozoa kwiqanda (ICSI).
Izindlela zokumisela i-antisperm antibodies kwabasetyhini
Kwimmeli yezesondo ezibuthathaka, iintsholongwane ze-antisperm zenziwa kwi-mucus yomlomo kunye naseplasma yegazi. Kunyanzelekile ukuvavanya ubukho bezilwanyana ezinjalo kwiibini ezizilungiselela ii-IVF.
Ngokuqhelekileyo ekunqumeni kwee-antibodies ze-antisperm, iindlela ezisekelwe ekumiselweni kwee-antibodies ezijoliswe kwi-anti-membrane antigen. Ezi ziquka iindlela ezifana:
- Uvavanyo lokusebenzisana kwe-spermatozoa kunye nomlenze we-mucous womlomo wesibeleko, okanye i-postcoital. Kumele kukhunjulwe ukuba esinye sezizathu eziqhelekileyo zokuvavanywa kwe-postcoital engafanelekanga kukuba kukho i-ACAT kwisidoda, oko kukuthi, ingxaki inxulumene nendoda, kungekhona kumlomo wesibeleko. Nangona kunjalo, ngokuqhelekileyo kunokwenzeka ukugcina intlangano yabasetyhini kunye nabasilisa. Uvavanyo lwe-Postcoital aluyithembeki kakhulu xa uhlola ukungabikho kwengqondo kwaye kuye ipesenti yeenkcukacha zamanga ziphezulu kakhulu. Yingakho ayisetyenziswanga yedwa, kuphela kunye nolwazi oluvela kuphando kwi-ACAT;
- Uvavanyo lwe-MAR. Le yindlela evumela ukuba ufumane inani le-spermatozoa edibene neengqungquthela zeeklasi IgA kunye ne-IgG, kwaye unceda ukwazi isiqu se-antisperm antibodies kwi-fluids ezifana ne-cervical mucus, i-spermoplasm, iplasma yegazi. Olu vavanyo lugqitywa ngamazwe ngamazwe njengomgangatho wokuxilonga we-ACAT, unomdla wokulinganisela kunye neenkcukacha eziphezulu;
- Uvavanyo lwe-latex agglutination luqulunqwa kwaye aluhlolwanga ngokupheleleyo uvavanyo lwe-ACAT. Olu vavanyo luyindlela echanekileyo yokuqonda i-ACAT kwiimvelo zamanzi, ezifana ne-plasma yegazi, i-semen, i-muscus yomlomo. Unobungakanani obuphezulu. Isethi yamathambo e-antibodies anokufunyanwa ngokusebenzisa le ndlela ayisoloko ihambelana nesethi yamathambo e-antibodies afunyenwe yizilingo ezimbini zangaphambilini, ngoko zivame ukudibaniswa ukuze zithole iziphumo ezithembekileyo;
- I-ELISA (i-enzyme immunoassay) - isetyenziselwa ukukhangela i-ACAT kwi-plasma yegazi. Kucingwa njengenye yezindlela ezongezelelweyo zokuxilonga i-ACAT. Iibhloko eziphezulu ze-ACAT, ezimiselwe yile ndlela kwiplasma yegazi kwabasetyhini, akunakunxulumaniswa nokungonakaliswa kokuqala kokukhulelwa.
Izindlela zokonyango
Unyango lwezibini ezithe zafunyaniswa ukuba zinezinga eliphezulu le-ACAT zinokuthi zenziwe ngeendlela ezahlukeneyo, kuxhomekeke kwiziphumo zoviwo. Okokuqala, kwiimeko ezininzi, indlela yokukhusela isetyenzisiweyo, oko kukuthi, ikhondom, ngokusetyenziswa rhoqo kwithuba leenyanga ezi-2-5 okanye kwimodi ephakathi, xa ikhondom ingasetyenziswanga kuphela ngaloo mihla ekhangeleka ukubonakala kokukhulelwa.
Ukunciphisa inani lembewu elingaphantsi komzimba wowesifazane lenza ukuhla kwe-antibodies kunye nokwandisa amathuba okukhulelwa.
Ngexesha elifanayo, unyango lunokumiselwa, okunciphisa i-viscosity ye-mucus yomlomo kunye nokuvimbela ukuhlanganiswa kwe-ACAT kumtshato womtshato. Ukuba iindlela zokuzikhusela aziyi kunceda, ngoko ziya ku-ISKI.