Ukungasebenzi kwe-endocrine kungenxa yesifo esiyinkimbinkimbi ye-hormonal disorders ekhokelela kwi-ovulation engavumelekanga okanye ukungabikho kwabo bonke abafazi. Kwindoda, le ntsholongwane ibonakaliswe ngokuphulwa kwe-spermatogenesis kunye nokunciphisa umgangatho wesilisa. Kwintliziyo ye-endocrine ukungabikho komthetho kuphulwa komsebenzi we-thyroid gland, i-hypothalamic-pituitary system, i-gonads.
Ukunyangwa kwexesha elifanelekileyo kwimiba enjalo kumzimba kubangela ukuqala kokukhulelwa okufunayo kwi-70-80% yazo zonke iimeko ze-endocrine infertility. Ngaphandle koko, indlela yodwa yokuphumeza umklamo ophumelelayo ngumntwana yindlela yokufaka umanyolo kwi-vitro. Ukukhethwa kwendlela yokwelashwa kwabangenasifo kugqityiwe kuphela emva kovavanyo olupheleleyo lwabafazi. Kubalulekile ukuba bobabini bomtshato bazalise uviwo kwaye bahlalutye. Kwaye ekubeni zichongiwe izizathu ezahlukahlukeneyo zokuphulwa kwemisebenzi yenkqubo yokuzala, unyango luvame ukuqala ngezi zizathu ezibaluleke kakhulu ekukhulelwe.
Ulwaphulo lwe-endocrine ukungabikho kwengqondo kufuneka luhlukaniswe kwaye lukhethwe ngabanye. Iimpawu zokukhetha indlela yokonyango yilezi: izibangela, ubude bokungabikho, ukungabikho kwezifo ezithintekayo.
Ukungakwazi ukusebenza kwesigaba sokubhala
Esinye sezizathu zokuphulwa kwe-ovulation. Olu lukhuseleko luhamba kunye nokungafaneleki ukusebenza komzimba ophuzi, obangela ukuba utshintsho lwangasese kwi-endometrium. Ngamanye amazwi, i-endometrium enjalo ayifanelekile ukufakelwa kwe-ovum. I-Pathology inokukhula ngezizathu ezihlukahlukeneyo: ngenxa ye-thyroid function, i-hyperprolactinemia esebenzayo, ukuvuvukala okungapheliyo kwezesondo, i-hyperandrogenism. Phantse rhoqo, unyango luqala ngokusetyenziswa kwe-estrogen-progestogen, enceda ukufezekisa i-ovulation. Ngokuqhelekileyo ukuhlanganiswa kwamanye amalungiselelo kunqunywe. Ubungakanani bemvume yabo yimizuzu engama-3-5. Kwixesha elizayo, kunokwenzeka ukuqhuba unyango usebenzisa izikhuthazo ezichanekileyo ze-ovulation.
Ukungabikho kwefuthe elihle, amalungiselelo aqukethe i-horonone ye-gonadotropic (i-menogon, i-humegon) ifakwe kwi-regimen yonyango, kunye ne-chorionic gonadotropin ilawulwa kwidayi ye-ovulatory phantsi kwesikhokelo se-ultrasound. Ukuba ukungafezeki kwesigaba se-luteal kungenxa ye-hyperprolactinemia okanye i-hyperandrogenism, ke i-ergotid erkaloids okanye i-dexamethasone (i-norprolac, i-parlodel) iyongezwa.
I-Syndrome ye-anovulation engapheliyo
Le ntsholongwane ingabangelwa zizifo ze-endocrine ezifana ne-hyperprolactinemia ye-non-tumor, kunye ne-tumor origin, i-polycystic ovary syndrome, i-hyperandrogenism ye-adrenal origin, i-hypothalamic-pituitary ukungasebenzi, kunye ne-syndrome ye-ovaries enganyangekiyo okanye i-syndrome ye-ovaries. Injongo yonyango yeengxaki ezinjalo kukukhuthaza ukuvuthwa kwe-ovulation. Kwimeko ye-polycystic ovary syndrome, umphumo wokuvalwa kwe-ovary ufikeleleke, kwaye u-ovarian stimulation uvuselelwe ngokusebenzisa i-gonadotropin okanye i-anti-estrogen. Ubungakanani bonyango ngama hormone luyi-3-5 imijikelezo. Xa kungabikho mpembelelo entle, ukungenelela kwintsebenziswano kuqhutyelwa ngendlela yokuguqulwa kwamatyala, i-biopsy e-bilateral ovarian, kunye ne-electrocautery yama-ovari. Le mi sebenzi yenziwa nge-laparoscopic access.
Ngokugqithiswa kokuqala kwama-ovari kunye nokuphuhliswa kwama-ovari anqandekayo, unyango olushukumisayo alusebenzi. Ngako oko, unyango olungenalo unyango luqhutyelwa ngokusebenzisa i-egg donor kwimvelaphi yonyango lwangaphandle, olwenziwe ngokusungulwa kwe-vitro fertilization kunye ne-tebrro transfer transfer.
Kwimveliso kukho uluvo lokuba impumelelo engama-100% kunyango lwe-hormonal infertility lingalindelwa ngokugula ngokuthe tye kwaye kwimeko apho ukuphulwa kwe-ovulation kubangelwa esinye sezizathu kwintsapho. Kodwa ekusebenzeni kwesi sibonakaliso sincinci kwaye sinama-60-70%.